Antioxidant and Cytotoxic Activities of Myrtaceae Essential Oils Rich in Terpenoids From Brazil

This work analyzed the chemical compositions and evaluated antioxidant cytotoxic activities of essential oils (EO) Eugenia patrisii (Epat), stipitata (Esti), Myrcia splendens (Mspl), sylvatica (Msyl), Psidium guajava (Pgua), guineense (Pgui-1 Pgui-2) from Brazilian Amazon. Sesquiterpenoids were found in high concentrations E. M. splendens, which rich E-caryophyllene (32.0% 45.8%); sylvatica, displayed germacrene D (11.8%) B (24.5%); P. that showed epi-β-bisabolol (16.1%) as main compound. However, samples monoterpenoids such limonene (Pgui-1: 30.2%; Pgui-2 30.4%) α-pinene 22.5%; Pgui-2: 17.7%). The a weak moderate DPPH assay, displaying inhibition rates 11.5% to 38.6% (at 10 mg/mL). All against human cancer cells by MTT method. Epat oil higher activity melanoma (SKMEL-19, IC 50 5.8 µg/mL), gastric (AGP01, 3.2 colon (HCT116, 6.7 µg/mL). Meanwhile, Pgua Pgui more active breast (MCF7, 12.4 µg/mL 11.6 µg/mL, respectively).